Concerta: Signs, Symptoms & Side Effects of Abuse
Written by Rob Alston
& Medically Reviewed by Dr. Jessica Pyhtila, PharmD
Medically Reviewed
Last updated: 03/10/2022
Key Takeaways
- Concerta is a Schedule II controlled substance used mainly for ADHD.
- The drug is commonly misused and abused, regardless of whether a person has a prescription.
- Short-term side effects of Concerta reflect its role as a stimulant that triggers the fight-or-flight response.
- Over the long term, Concerta misuse can be dangerous because the body is in a chronic fight-or-flight state.
- Overdose of Concerta can be deadly and is a medical emergency.
- Both behavioral and drug-seeking signs may alert you to someone struggling with Concerta.
Concerta misuse can lead to short and long-term side effects that dangerously rev up the central nervous system.
Concerta is one of the brand names for the drug methylphenidate. As a central nervous system stimulant, Concerta is mainly used to treat attention-deficit hyperactivity disorder or ADHD. The drug is commonly used in ADHD and can help people with the disorder. Unfortunately, it also has a high risk of abuse and is, therefore, a Schedule II controlled substance. Although most people prescribed Concerta will use it appropriately, some people may misuse it.
Further, Concerta is sometimes abused by people who do not have a prescription and use the drug illicitly. If you or a loved one are concerned about someone’s Concerta use, knowing the signs and symptoms of possible abuse is important.
Concerta Side Effects
Most of Concerta’s side effects reflect its mechanism as a central nervous system stimulant. Concerta works by increasing the levels of the brain chemicals dopamine and norepinephrine. While dopamine can cause euphoria, norepinephrine can trigger the body’s fight-or-flight response. In adults, the most common side effects of Concerta are:
Common Concerta Side Effects
Decreased appetite
Headache
Dry mouth
Nausea
Problems sleeping
Anxiety
Dizziness
Weight loss
Irritability
Sweating
Short-Term Side Effects
Over the short term, side effects of Concerta abuse are similar to those of other stimulants. Concerta works in part by increasing brain chemicals like norepinephrine, which stimulates the body. These chemicals activate the sympathetic nervous system and the fight-or-flight response. Short-term side effects are often similar to the fight-or-flight response and include:
- High blood pressure
- Fast heart rate
- Elevated body temperature
- Decreased need for sleep
- Loss of appetite
Long-Term Side Effects
Abuse of stimulants like Concerta over the long term can lead to many medical problems. The body is not designed to be in permanent fight-or-flight mode like Concerta abuse can cause. Because the body is constantly stimulated and the sympathetic nervous system is always active, problems can result. These include:
- Hostility
- Paranoia
- Malnutrition
- Cardiovascular problems like stroke
Concerta Overdose Symptoms
Concerta overdose symptoms are similar to those of other stimulants. This is mainly because stimulants work by increasing activity in the central nervous system, and overdose symptoms reflect that. Symptoms include:
Symptoms of Concerta Overdose
Vomiting
Agitation
Dry mouth
Twitching muscles
Seizure or convulsion
Confusion
Hallucinations
Sweating
Headache
Fever
Fast heartbeat
Pounding heart
Irregular pulse
High blood pressure
Wide pupils
It is crucial to seek emergency medical attention if you think someone has overdosed on Concerta. People have died from heart attack and stroke after a stimulant overdose. If you are unsure what to do, call 911 or Poison Control at (800) 222-1222. You may also seek help at a detox center. Because Concerta is a long-acting drug that keeps releasing for hours after the last dose, symptoms could worsen and become deadly.
How Is Concerta Abused?
Concerta is commonly abused or misused. Up to 25% of people prescribed a stimulant like Concerta misuse the drug. Most often, people take more of the drug than was prescribed. However, sometimes people without prescriptions for Concerta obtain the medication as well, either by stealing or buying it from people with a prescription. Most people who use stimulants like Concerta illicitly are under the age of 25 and get the drug from a friend. People without prescriptions for Concerta often take the drug to:
- Stay awake
- Improve attention
- Be alert
- Feel less drunk after drinking
- Get high
- Suppress appetite
- Prevent withdrawal from other stimulants, such as cocaine
Concerta is designed to only be taken orally. The medicine has a complex drug-release system that requires fluid to slowly push the drug out of the tablet over the course of hours. It does not work well if it is not used in this manner.
For this reason, Concerta is generally only taken by mouth and not other routes. Attempts to take the drug by other routes like snorting does not cause a high due to the complex drug design. However, other forms of methylphenidate may be snorted or injected.
Dangerous Drug Interactions
Concerta has several dangerous drug-drug interactions. These include:
Concertas Interactions with other Drugs
Monoamine Oxidase Inhibitors, or MAOIs
Using Concerta within 14 days of using an MAOI can cause dangerous spikes in blood pressure. Although rarely used, MAOIs include:
Isocarboxaxid, brand name Marplan
Phenelzine, brand name Nardil
Selegiline, brand names Emsam and Zelapar
Tranylcypromine, brand name Parnate
Vasopressors
These drugs are designed to increase blood pressure. They are rarely given outside the hospital and include:
Epinephrine
Norepinephrine
Isoproterenol
Dobutamine
Warfarin
Concerta can increase the amount of this blood thinner in the body, leading to a higher risk of bleeding.
Seizure Drugs
Concerta may increase the concentration of certain seizure drugs in the body. Although seizure drugs are most often used to prevent seizure, they can sometimes be used for other health problems. Seizure drugs that may interact with Concerta are:
Phenytoin
Primidone
Phenobarbital
Antidepressants
Concerta may increase the level of some antidepressants, like:
Amitriptyline
Sertraline, brand name Zoloft
Fluoxetine, brand name Prozac
Escitalopram, brand name Lexapro
Further, the amount of Concerta in the blood may also be increased by some drugs. These include:
Alcohol
Drinking alcohol with Concerta is risky for many reasons. Besides increasing the amount of Concerta in the body, combining the substances may make a person feel less drunk than they really are. This can be very dangerous if they decide to drive a car because they think they are sober.
Antipsychotic Drugs
These drugs can be used for many different mental health conditions and include:
Aripiprazole, brand name Abilify
Olanzapine, brand name Zyprexa
Risperidone, brand name Risperdal
Ziprasidone, brand name Geodon
Bupropion
This drug is sometimes used for mood and depression. However, it can also be used to help stop smoking. Because bupropion can increase seizure risk, combining it with Concerta, which can also increase seizure risk, may be dangerous.
Cannabis
Cannabis and cannabis-containing drugs can increase the level of Concerta in the body. Because cannabis can increase heart rate, and so can Concerta, they may have an additive effect on the heart.
Signs Of Concerta Addiction
Someone struggling with Concerta use may start showing symptoms. Many symptoms reflect attitude and behavior and are common to substance abuse regardless of the drug being used. Substance abuse symptoms include:
Signs of Concerta Abuse
Being socially withdrawn
Avoiding family or old friends
Sending an abnormal amount of time with new friends
Losing interest in things that once gave pleasure
Having mood swings
Acting irritable
Having difficulty sleeping, or sleeping at strange times
Forgetting appointments
Missing deadlines
Having problems at work or school
Having problems with family
Acting recklessly
Having legal problems
Because Concerta is a Schedule II controlled substance, doctors must prescribe it as a 30 day supply with no refills. Many people who misuse Concerta show what are called drug-seeking behaviors around medical staff. These behaviors include:
- Constantly asking their doctor to write a new prescription before one is due
- Asking the pharmacy to fill Concerta early
- Claiming the pharmacy did not give as much Concerta as they were supposed to
- Saying they lost their Concerta
- Seeking Concerta prescriptions from multiple doctors
- Trying to fill a fake Concerta prescription at the pharmacy
- Going to an urgent care or the emergency room for a prescription
Related Topic: How long does it take to detox from methylphenidate?
View Sources
Substance Abuse and Mental Health Services Administration. “Adults With Attention Deficit Hyperactivity Disorder and Substance Use Disorders.” Fall 2015. Accessed October 6, 2019.
Drug Enforcement Administration. “Methylphenidate.” July 2019. Accessed October 5, 2019.
National Institute on Drug Abuse. “Stimulant ADHD Medications: Methylphenidate and Amphetamines.” January 2014. Accessed October 5, 2019.
U.S. National Library of Medicine. “Concerta.” August 15, 2019. Accessed October 6, 2019.
Jaffe, Steven L. “Failed Attempts at Intranasal Abuse of Concerta.” Journal of the American Academy of Child and Adolescent Psychiatry, January 2002. Accessed October 6, 2019.
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